IC50 and CC50

IC50 is the minimum inhibition concentration for inhibiting 50% of the pathogen and CC50 is the Cytotoxic concentration of the compound to cause death to 50% of viable cells in the host. These are measured through dilution assays of the selected compound and they are added to virus infected host cells.

The Ideal situation is to have the IC50 concentration below the CC50 concentration and your CC50 as high as possible.

This mean that you kill the pathogen before killing the host. These are important factors to consider when developing anti microbial compounds.

SI = CC50/IC50 

SI is a index value that gives you an idea about the selectivity. You need this to be a high value number which means that you achieve killing the virus before your host, i.e. the compound has selectivity towards your virus and not your host.

Why do we have to measure IC50, CC50 and SI?. Available from: https://www.researchgate.net/post/Why_do_we_have_to_measure_IC50_CC50_and_SI

Enamines

Secondary amines reacts with carbonyl compounds to form enamines, following the link you can find the mechanism of enamines formation. Enamines.pdf

Stable Imines

Here you some examples of stabile imines. Just follow the link Stable imines.pdf

Imines

Imines are the nitrogen analogous of carbonyl compounds, they are formed when any primary amine reacts with a ketone or aldehyde under appropriate conditions.

Following this dropbox link Imines.pdf you can find a brief description and some notes about Imines, how to make them, their stability and so on.