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sabato 2 dicembre 2017

Hard and Soft Nucleophiles


Hey there!! Here it is a small table with some general characteristics about Hard and Soft nucleophiles, I hop e it could ne useful.

HARD NUCLEOPHILES                  SOFT NUCLEOPHILES
 
  Small                                                 large
  Charged                                            neutral
  Basic (HX is a weak acid)             not basic (HY is a strong acid)
  Low-energy HOMO                         high energy HOMO
  Like to attack C=O                          like to attack saturated carbon
  Ex. RO-, NH2-, MeLi                         ex. RS-, I-, R3P:

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